Samama Charles Marc


Research theme : Theme 2 – Part 2

Phone: 01 42 34 95 51


Charles Marc Samama is 61 yo. He is currently Professor in the Department of Anaesthesia and Intensive Care of Cochin University Hospital in Paris, France.

Professor Samama is the past-Chair of the Scientific Committee of the European Society of Anaesthesiology (ESA) and also the past-Chair of the new Scientific Subcommittee on Perioperative and Critical Care Thrombosis and Hemostasis of the International Society on Thrombosis and Haemostasis (ISTH). He is the President of the Network for the Advancement of Patient Blood Management, Haemostasis and Thrombosis (NATA).

He has published more than 220 peer-reviewed articles and reviews (H index = 40). He has co-authored the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines 8th edition (“Prevention of venous thromboembolism”) and 9th edition (“Prevention in VTE in non-orthopaedic surgical patients”). He is co-authoring the 10th edition (“Perioperative Management of Antithrombotic Agents”).

He has co-authored the 2013 ESA Guidelines on Management of severe perioperative bleeding and the 2017 update. He chairs the ESA Task Force for the prevention on perioperative venous thromboembolism (guidelines published in February 2018 in the Eur J Anaethesiol, IF 3,98).

Major publications 2020 / 2016

Scientific and Standardization Committee Communication: Guidance document on the periprocedural management of patients on chronic oral anticoagulant therapy: Recommendations for standardized reporting of procedural/surgical bleed risk and patient-specific thromboembolic risk. Alex C Spyropoulos, Karim Brohi, Joseph Caprini, Charles Marc Samama, Deborah Siegal, Alfonso Tafur, Peter Verhamme, James D Douketis, SSC Subcommittee on Perioperative and Critical Care Thrombosis and Haemostasis of the International Society on Thrombosis and Haemostasis – 2019 Nov – PMID: 31436045 DOI: 10.1111/jth.14598

Postoperative Venous Thromboembolism Prophylaxis: Changes in the Daily Clinical Practice, Modified Guidelines. Charles Marc Samama – 2020 Feb – PMID: 31443112 DOI: 10.1055/s-0039-1694994

International Delphi survey of the ESTS/AATS/ISTH task force on venous thromboembolism prophylaxis in thoracic surgery: the role of extended post-discharge prophylaxis. John Agzarian, Virginia Litle, Lori-Ann Linkins, Alessandro Brunelli, Laura Schneider, Peter Kestenholz, Hui Li, Gaetano Rocco, Philippe Girard, Jun Nakajima, Charles Marc Samama, Marco Scarci, Masaki Anraku, Pierre-Emmanuel Falcoz, Luca Bertolaccini, Jules Lin, Sudish Murthy, Wayne Hofstetter, Meinoshin Okumura, Piergiorgio Solli, Fabrizio Minervini, Alan Kirk, James Douketis, Yaron Shargall – 2020 May – PMID: 31769796 DOI: 10.1093/ejcts/ezz319

Andexanet alfa for the reversal of factor Xa inhibitors. Favresse J, Hardy M, van Dievoet MA, Sennesael AL, Douxfils J, Samama CM, Vornicu O, Dincq AS, Lessire S, Mullier F. Expert Opin Biol Ther. 2019 May;19(5):387-397. doi: 10.1080/14712598.2019.1599355. Epub 2019 Apr 11.

The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Spahn DR, Bouillon B, Cerny V, Duranteau J, Filipescu D, Hunt BJ, Komadina R, Maegele M, Nardi G, Riddez L, Samama CM, Vincent JL, Rossaint R. Crit Care. 2019 Mar 27;23(1):98. doi: 10.1186/s13054-019-2347-3.

Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement. Muñoz M, Stensballe J, Ducloy-Bouthors AS, Bonnet MP, De Robertis E, Fornet I, Goffinet F, Hofer S, Holzgreve W, Manrique S, Nizard J, Christory F, Samama CM, Hardy JF. Blood Transfus. 2019 Mar;17(2):112-136. doi: 10.2450/2019.0245-18.

Fast-Track Procedures in Major Orthopaedic Surgery: Is Venous Thromboembolism Prophylaxis Still Mandatory? Samama CM. Thromb Haemost. 2019 Jan;119(1):3-5. doi: 10.1055/s-0038-1676613.

Stopping or maintaining oral anticoagulation in patients undergoing photoselective vaporization of the prostate (SOAP) surgery for benign prostate obstruction: study protocol for a multicentre randomized controlled trial. Charbonneau H, Pasquié M, Peyronnet B, Descazeaud A, Barry-Delongchamps N, Della Negra E, Mathieu R, Karsenty G, Long JA, Ballereau C, Azzouzi AR, Pradère B, Bruyère F, Fournier G, Lebdai S, Calves J, Corbel L, Vincendeau S, Fiard G, Thuillier C, Descotes JL, Colin P, Culty T, Hesbois A, Fuzier V, Savy N, Pathak A, Albaladejo P, Samama CM, Guerrero F, Misraï V. Trials. 2018 Dec 27;19(1):705. doi: 10.1186/s13063-018-3066-9.

Comparative effectiveness of direct oral anticoagulants versus low-molecular weight heparins for the prevention of venous thromboembolism after total hip or knee replacement: A nationwide database cohort study. Blin P, Samama CM, Sautet A, Benichou J, Lignot-Maleyran S, Lamarque S, Lorrain S, Lassalle R, Droz-Perroteau C, Mismetti P, Moore N. Pharmacol Res. 2019 Mar;141:201-207. doi: 10.1016/j.phrs.2018.12.018.

Postoperative outcomes of frequent exacerbator patients with Chronic Obstructive Pulmonary Disease after resection of Non-Small Cells Lung Cancer. Demiri S, Lorut C, Rabbat A, Luu van Lang D, Lefebvre A, Regnard JF, Samama CM, Dusser D, Roche N, Alifano M. COPD. 2018 Jun-Aug;15(4):361-368. doi: 10.1080/15412555.2018.1519784.

Modified ROTEM for the detection of rivaroxaban and apixaban anticoagulant activity in whole blood: A diagnostic test study. Pailleret C, Jourdi G, Siguret V, Gouin-Thibault I, Gandrille S, Stepanian A, Curis E, Golmard JL, Gaussem P, Le Bonniec B, Samama CM. Eur J Anaesthesiol. 2019 Jun;36(6):449-456. doi: 10.1097/EJA.0000000000000903.

The utility of viscoelastic methods in the prevention and treatment of bleeding and hospital-associated venous thromboembolism in perioperative care: guidance from the SSC of the ISTH. Thomas W, Samama CM, Greinacher A, Hunt BJ; Subcommittee on Perioperative and Critical Care. J Thromb Haemost. 2018 Nov;16(11):2336-2340. doi: 10.1111/jth.14265.

Use of factor concentrates for the management of perioperative bleeding: reply. Godier A, Greinacher A, Faraoni D, Levy JH, Samama CM. J Thromb Haemost. 2018 Oct;16(10):2113-2115. doi: 10.1111/jth.14262.

Management of bleeding and emergency invasive procedures in patients on dabigatran: Updated guidelines from the French Working Group on Perioperative Haemostasis (GIHP) – September 2016. Albaladejo P, Pernod G, Godier A, de Maistre E, Rosencher N, Mas JL, Fontana P, Samama CM, Steib A, Schlumberger S, Marret E, Roullet S, Susen S, Madi-Jebara S, Nguyen P, Schved JF, Bonhomme F, Sié P; members of the French Working Group on Perioperative Haemostasis. Anaesth Crit Care Pain Med. 2018 Aug;37(4):391-399. doi: 10.1016/j.accpm.2018.04.009.

The place of fibrinogen concentrates in the management of perioperative bleeding: A position paper from the Francophone Working Group on Perioperative Haemostasis (GIHP). Samama CM, Ickx B, Ozier Y, Steib A, Susen S, Godier A. Anaesth Crit Care Pain Med. 2018 Aug;37(4):355-365. doi: 10.1016/j.accpm.2018.04.002. Epub 2018 Apr 13. Review

Thromboprophylaxis for ambulatory surgery: Results from a prospective national cohort. Samama CM, Benhamou D, Aubrun F, Bosson JL, Albaladejo P. Anaesth Crit Care Pain Med. 2018 Aug;37(4):343-347. doi: 10.1016/j.accpm.2018.01.003. Epub 2018 Feb 15

Management of antiplatelet therapy in patients undergoing elective invasive procedures: Proposals from the French Working Group on perioperative hemostasis (GIHP) and the French Study Group on thrombosis and hemostasis (GFHT). In collaboration with the French Society for Anesthesia and Intensive Care (SFAR). Godier A, Fontana P, Motte S, Steib A, Bonhomme F, Schlumberger S, Lecompte T, Rosencher N, Susen S, Vincentelli A, Gruel Y, Albaladejo P, Collet JP; French Working Group on perioperative hemostasis (GIHP). Arch Cardiovasc Dis. 2018 Mar;111(3):210-223. doi: 10.1016/j.acvd.2017.12.004. Epub 2018 Feb 3. Review.

Evaluation of recombinant factor VIIa, tranexamic acid and desmopressin to reduce prasugrel-related bleeding: A randomised, placebo-controlled study in a rabbit model. Bonhomme F, Lecompte T, Samama CM, Godier A, Fontana P. Eur J Anaesthesiol. 2018 Mar;35(3):208-214. doi: 10.1097/EJA.0000000000000775

Sepsis and thrombosis: An unusual extensive inferior vena cava thrombosis. Fromentin M, Talec P, Stephanazzi J, Samama CM. Anaesth Crit Care Pain Med. 2018 Aug;37(4):377-378. doi: 10.1016/j.accpm.2017.11.008.

Management of antiplatelet therapy in patients undergoing elective invasive procedures. Proposals from the French Working Group on perioperative haemostasis (GIHP) and the French Study Group on thrombosis and haemostasis (GFHT). In collaboration with the French Society for Anaesthesia and Intensive Care Medicine (SFAR). Godier A, Fontana P, Motte S, Steib A, Bonhomme F, Schlumberger S, Lecompte T, Rosencher N, Susen S, Vincentelli A, Gruel Y, Albaladejo P, Collet JP; members of the French Working Group on perioperative haemostasis (GIHP). Anaesth Crit Care Pain Med. 2018 Aug;37(4):379-389. doi: 10.1016/j.accpm.2017.12.012.

A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study. Guérin C, Beuret P, Constantin JM, Bellani G, Garcia-Olivares P, Roca O, Meertens JH, Maia PA, Becher T, Peterson J, Larsson A, Gurjar M, Hajjej Z, Kovari F, Assiri AH, Mainas E, Hasan MS, Morocho-Tutillo DR, Baboi L, Chrétien JM, François G, Ayzac L, Chen L, Brochard L, Mercat A; investigators of the APRONET Study Group, the REVA Network, the Réseau recherche de la Société Française d’Anesthésie-Réanimation (SFAR-recherche) and the ESICM Trials Group. Intensive Care Med. 2018 Jan;44(1):22-37. doi: 10.1007/s00134-017-4996-5.

Laboratory testing in patients treated with direct oral anticoagulants: a practical guide for clinicians. Douxfils J, Ageno W, Samama CM, Lessire S, Ten Cate H, Verhamme P, Dogné JM, Mullier F. J Thromb Haemost. 2018 Feb;16(2):209-219. doi: 10.1111/jth.13912.

European Guidelines on perioperative venous thromboembolism prophylaxis: Executive summary. Afshari A, Ageno W, Ahmed A, Duranteau J, Faraoni D, Kozek-Langenecker S, Llau J, Nizard J, Solca M, Stensballe J, Thienpont E, Tsiridis E, Venclauskas L, Samama CM; ESA VTE Guidelines Task Force. Eur J Anaesthesiol. 2018 Feb;35(2):77-83. doi: 10.1097/EJA.0000000000000729.

European guidelines on perioperative venous thromboembolism prophylaxis. Samama CM, Afshari A; ESA VTE Guidelines Task Force. Eur J Anaesthesiol. 2018 Feb;35(2):73-76. doi: 10.1097/EJA.0000000000000702.

European guidelines on perioperative venous thromboembolism prophylaxis: Aspirin. Jenny JY, Pabinger I, Samama CM; ESA VTE Guidelines Task Force. Eur J Anaesthesiol. 2018 Feb;35(2):123-129. doi: 10.1097/EJA.0000000000000728

Research ethics committee approval as reported for abstracts submitted to the annual Euroanaesthesia meeting. McConnell P, Kaufman N, De Hert S, Samama CM, Molnar Z, Einav S. Eur J Anaesthesiol. 2017 Dec;34(12):824-830. doi: 10.1097/EJA.0000000000000669.

A retrospective comparison between delayed and early hip fracture surgery in patients taking clopidogrel: same total bleeding but different timing of blood transfusion. Pailleret C, Ait Hamou Z, Rosencher N, Samama CM, Eyraud V, Chilot F, Baillard C. Int Orthop. 2017 Sep;41(9):1839-1844. doi: 10.1007/s00264-017-3571-6.

Patient blood management in obstetrics: management of anaemia and haematinic deficiencies in pregnancy and in the post-partum period: NATA consensus statement. Muñoz M, Peña-Rosas JP, Robinson S, Milman N, Holzgreve W, Breymann C, Goffinet F, Nizard J, Christory F, Samama CM, Hardy JF. Transfus Med. 2018 Feb;28(1):22-39. doi: 10.1111/tme.12443.

Perioperative management of patients on direct oral anticoagulants. Dubois V, Dincq AS, Douxfils J, Ickx B, Samama CM, Dogné JM, Gourdin M, Chatelain B, Mullier F, Lessire S. Thromb J. 2017 May 15;15:14. doi: 10.1186/s12959-017-0137-1.

Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016. Kozek-Langenecker SA, Ahmed AB, Afshari A, Albaladejo P, Aldecoa C, Barauskas G, De Robertis E, Faraoni D, Filipescu DC, Fries D, Haas T, Jacob M, Lancé MD, Pitarch JVL, Mallett S, Meier J, Molnar ZL, Rahe-Meyer N, Samama CM, Stensballe J, Van der Linden PJF, Wikkelsø AJ, Wouters P, Wyffels P, Zacharowski K. Eur J Anaesthesiol. 2017 Jun;34(6):332-395. doi: 10.1097/EJA.0000000000000630.

Management of Severe Bleeding in Patients Treated with Direct Oral Anticoagulants: An Observational Registry Analysis. Albaladejo P, Samama CM, Sié P, Kauffmann S, Mémier V, Suchon P, Viallon A, David JS, Gruel Y, Bellamy L, de Maistre E, Romegoux P, Thoret S, Pernod G, Bosson JL; GIHP-NACO Study Group. Anesthesiology. 2017 Jul;127(1):111-120. doi: 10.1097/ALN.0000000000001631.

The structure, organisation and perioperative management of ambulatory surgery and anaesthesia in France: Methodology of the SFAR-OPERA study. Albaladejo P, Aubrun F, Samama CM, Jouffroy L, Beaussier M, Benhamou D, Romegoux P, Skaare K, Bosson JL, Ecoffey C. Anaesth Crit Care Pain Med. 2017 Oct;36(5):307-312. doi: 10.1016/j.accpm.2016.10.002.

Reply to: assessment of haemostasis in patients with liver cirrhosis. Lentschener C, Flaujac C, Gouin-Thibault I, Samama CM. Eur J Anaesthesiol. 2017 Jan;34(1):35-36.

Open access to research data: the two sides of the coin. De Hert S, Samama CM. Eur J Anaesthesiol. 2017 Jan;34(1):1-3.

Early ambulation and prevention of post-operative thrombo-embolic risk. Talec P, Gaujoux S, Samama CM. J Visc Surg. 2016 Dec;153(6S):S11-S14. doi: 10.1016/j.jviscsurg.2016.09.002. Epub 2016 Oct 24. Review.

Idarucizumab administration for reversing dabigatran effect in an acute kidney injured patient with bleeding. Quintard H, Viard D, Drici MD, Ruetsch C, Samama CM, Ichai C. Thromb Haemost. 2017 Jan 5;117(1):196-197. doi: 10.1160/TH16-06-0445. Epub 2016 Oct 13.

Bicarbonate-buffered ropivacaine-mepivacaine solution for medial caruncle anaesthesia. Guerrier G, Boutboul D, Chanat C, Samama CM, Baillard C. Anaesth Crit Care Pain Med. 2017 Aug;36(4):219-221. doi: 10.1016/j.accpm.2016.09.007. Epub 2016 Oct 6.

First description of herpes simplex virus type 1 epididymo-orchitis: A new clinical form of herpes simplex virus infection during septic shock? Fromentin DM, Gauzit R, Gille B, Samama CM. IDCases. 2016 Sep 15;6:26-8. doi: 10.1016/j.idcr.2016.09.004.

Pulmonary embolism of cement after knee prosthesis replacement. Talec P, Fromentin M, Samama CM. Anaesth Crit Care Pain Med. 2017 Feb;36(1):71-72. doi: 10.1016/j.accpm.2016.05.011. Epub 2016 Sep 23.

Management of direct oral anticoagulants in patients undergoing elective surgeries and invasive procedures: Updated guidelines from the French Working Group on Perioperative Hemostasis (GIHP) – September 2015. Albaladejo P, Bonhomme F, Blais N, Collet JP, Faraoni D, Fontana P, Godier A, Llau J, Longrois D, Marret E, Mismetti P, Rosencher N, Roullet S, Samama CM, Schved JF, Sié P, Steib A, Susen S; French Working Group on Perioperative Hemostasis (GIHP). Anaesth Crit Care Pain Med. 2017 Feb;36(1):73-76. doi: 10.1016/j.accpm.2016.09.002.

Comment on ‘The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome’. Lentschener C, Nicco C, Terris B, Samama CM, Coriat R. Br J Cancer. 2016 Oct 11;115(8):e7. doi: 10.1038/bjc.2016.242.

Correction of prasugrel-related bleeding by prophylactic transfusion of human platelets in a rabbit model. Bonhomme F, Godier A, Samama CM, Lecompte T, Fontana P. Transfusion. 2016 Oct;56(10):2618-2626. doi: 10.1111/trf.13765.

Coagulation following major liver resection. Lentschener C, Samama CM. Anaesthesia. 2016 Sep;71(9):1118-9. doi: 10.1111/anae.13587.

Risk factors for intraoperative hypertension in patients undergoing cataract surgery under topical anaesthesia. Guerrier G, Rondet S, Hallal D, Levy J, Bourdon H, Brezin AP, Samama CM. Anaesth Crit Care Pain Med. 2016 Oct;35(5):343-346. doi: 10.1016/j.accpm.2016.01.005.

Postoperative bleeding and coagulation disorders. Samama CM. Curr Opin Crit Care. 2016 Aug;22(4):365-9. doi: 10.1097/MCC.0000000000000317. Review.

Observational study of dabigatran etexilate 150mg in patients with moderate renal impairment undergoing elective total hip or knee replacement. Samama CM, Rosencher N, Kleine E, Feuring M, Brueckmann M, Clemens A, Gullberg J, Frostick SP. Thromb Res. 2016 Jul;143:103-10. doi: 10.1016/j.thromres.2016.05.014.

Fibrinogen Concentrates for Acquired Fibrinogen Deficiencies? Samama CM. Semin Thromb Hemost. 2016 Jun;42(4):375-80. doi: 10.1055/s-0036-1572325.

Dabigatran etexilate for thromboprophylaxis in over 5000 hip or knee replacement patients in a real-world clinical setting. Rosencher N, Samama CM, Feuring M, Brueckmann M, Kleine E, Clemens A, Frostick S. Thromb J. 2016 Apr 1;14:8. doi: 10.1186/s12959-016-0082-4.

Intraoperative transfusion practices in Europe. Meier J, Filipescu D, Kozek-Langenecker S, Llau Pitarch J, Mallett S, Martus P, Matot I; ETPOS collaborators. Br J Anaesth. 2016 Feb;116(2):255-61. doi: 10.1093/bja/aev456.

New anticoagulants in ambulatory anaesthesia. Samama CM. Eur J Anaesthesiol. 2016 Feb;33(2):69-71. doi: 10.1097/EJA.0000000000000357.

Preoperative risk factors of hemodynamic instability during laparoscopic adrenalectomy for pheochromocytoma. Gaujoux S, Bonnet S, Lentschener C, Thillois JM, Duboc D, Bertherat J, Samama CM, Dousset B. Surg Endosc. 2016 Jul;30(7):2984-93. doi: 10.1007/s00464-015-4587-x.

Comparison of a Supraglottic Gel Device and an Endotracheal Tube in Keratoplasty Performed Under General Anesthesia: A Randomized Clinical Trial. Guerrier G, Boutboul D, Rondet S, Hallal D, Levy J, Sjögren L, Legeais JM, Nicolau R, Mehanna C, Bourges JL, Samama CM. Cornea. 2016 Jan;35(1):37-40. doi: 10.1097/ICO.0000000000000632.

The effectiveness of platelet supplementation for the reversal of ticagrelor-induced inhibition of platelet aggregation: An in-vitro study. Martin AC, Berndt C, Calmette L, Philip I, Decouture B, Gaussem P, Gouin-Thibault I, Samama CM, Bachelot-Loza C, Godier A. Eur J Anaesthesiol. 2016 May;33(5):361-7. doi: 10.1097/EJA.0000000000000348.

Assessment of haemostasis in patients with cirrhosis: Relevance of the ROTEM tests?: A prospective, cross-sectional study. Lentschener C, Flaujac C, Ibrahim F, Gouin-Thibault I, Bazin M, Sogni P, Samama CM. Eur J Anaesthesiol. 2016 Feb;33(2):126-33. doi: 10.1097/EJA.0000000000000322.